Category

Khavinson Bioregulators

Short peptides from the Russian bioregulator research program (Cytomaxes).

Bronchogen

Bronchogen (Ala-Glu-Asp-Leu, AEDL, Khavinson bronchial bioregulator)

Khavinson Bioregulators
Evidence: Preclinical

Khavinson tetrapeptide bioregulator (Ala-Glu-Asp-Leu) targeting bronchial and airway tissue. Developed at the St. Petersburg Institute of Bioregulation and Gerontology. Animal studies report bronchial epithelium effects. No Western clinical trials.

Recovery

Cardiogen

Alanyl-Glutamyl-Aspartyl-Arginine (Ala-Glu-Asp-Arg / AEDR) — Khavinson Heart Cytogen

Khavinson Bioregulators
Evidence: Preclinical

Synthetic Ala-Glu-Asp-Arg tetrapeptide developed by the Khavinson group as the cardiac Cytogen. Sequence is well-defined (AEDR, ~489.5 Da), but human trial evidence is Russian-institution dominated.

Recovery

Cartalax

Cartalax — Ala-Glu-Asp (AED) Khavinson Cartilage Cytogen

Khavinson Bioregulators
Evidence: Preclinical

Synthetic Ala-Glu-Asp tripeptide derived from type XI collagen alpha-1 chain. Khavinson cartilage Cytogen with reported chondrocyte proliferation effects in cell culture.

RecoveryTissue Healing

Cerluten

Cerluten — Khavinson Brain Cytomax

Khavinson Bioregulators
Evidence: Preclinical

Khavinson brain Cytomax peptide complex extracted from young calf brain tissue. Marketed for CNS support in cognitive aging and post-stroke recovery.

RecoveryCognitive Enhancement

Chonluten

Chonluten A-21 — Khavinson Bronchial Cytomax

Khavinson Bioregulators
Evidence: Preclinical

Khavinson bronchial Cytomax peptide complex extracted from young calf bronchial epithelium. Marketed for respiratory tract support. Russian-network clinical observation data only.

Recovery

Cortagen

Cortagen — Ala-Glu-Asp-Pro (AEDP) Khavinson Cortex Cytogen

Khavinson Bioregulators
Evidence: Preclinical

Synthetic Ala-Glu-Asp-Pro tetrapeptide derived by epitope mapping from Cortexin brain extract. Khavinson cortex Cytogen targeting central nervous system gene expression.

RecoveryCognitive Enhancement

Crystagen

Crystagen — Glu-Asp-Pro (EDP) Khavinson Immune Cytogen

Khavinson Bioregulators
Evidence: Preclinical

Synthetic Glu-Asp-Pro tripeptide identified by epitope mapping as a principal active component of Thymalin. Marketed as immune Cytogen in the Khavinson system.

Recovery

Endoluten

Endoluten A-8 — Khavinson Pineal Cytomax

Khavinson Bioregulators
Evidence: Preclinical

Khavinson pineal Cytomax peptide complex extracted from young calf pineal gland. Marketed for circadian rhythm, sleep, and longevity. Russian-network clinical observation data only.

RecoverySleep Quality

Epitalon

Epitalon (Epithalon, Epithalamin tetrapeptide)

Khavinson Bioregulators
Evidence: Preclinical

Synthetic tetrapeptide developed by Vladimir Khavinson; telomerase activation claims rest on Khavinson-group rodent studies and small Russian observational reports.

Skin Anti-Aging

Glandokort

Glandokort A-13 — Khavinson Adrenal Cytomax

Khavinson Bioregulators
Evidence: Preclinical

Khavinson adrenal Cytomax peptide complex extracted from young calf adrenal tissue. Marketed for adrenal support. No FDA approval, evidence is Russian-network dominated.

Recovery

Livagen

Livagen — Lys-Glu-Asp-Ala (KEDA) Khavinson Liver Cytogen

Khavinson Bioregulators
Evidence: Preclinical

Synthetic Lys-Glu-Asp-Ala tetrapeptide developed as the Khavinson liver and immune Cytogen. Documented chromatin decondensation effects in cell culture.

Recovery

Ovagen

Glutamyl-Aspartyl-Leucine (Glu-Asp-Leu / EDL) — Khavinson Liver Cytogen

Khavinson Bioregulators
Evidence: Preclinical

Synthetic Glu-Asp-Leu tripeptide developed by the Khavinson group as a liver and GI cytogen. Sequence is well-defined (PubChem 444128), but human trial evidence is dominated by Russian-institution publications.

RecoveryGut Health

Pancragen

Lysyl-Glutamyl-Aspartyl-Tryptophan (Lys-Glu-Asp-Trp / KEDW) — Khavinson Pancreas Cytogen

Khavinson Bioregulators
Evidence: Preclinical

Synthetic Lys-Glu-Asp-Trp tetrapeptide developed by the Khavinson group as the pancreas Cytogen. Russian-network clinical observation data on glycemic markers; no independent Western RCT.

Recovery

Pinealon

Pinealon (Glu-Asp-Arg, EDR tripeptide, Khavinson brain bioregulator)

Khavinson Bioregulators
Evidence: Preclinical

Khavinson tripeptide bioregulator (Glu-Asp-Arg) developed at the St. Petersburg Institute of Bioregulation and Gerontology. Brain-tissue-specific cytogen. Animal studies report neuroprotection and cognitive effects. No Western clinical trials.

Cognitive Enhancement

Prostamax

Lysyl-Glutamyl-Aspartyl-Proline (Lys-Glu-Asp-Pro / KEDP) — Khavinson Prostate Cytogen

Khavinson Bioregulators
Evidence: Preclinical

Synthetic Lys-Glu-Asp-Pro tetrapeptide developed by the Khavinson group as the prostate Cytogen. Russian-network clinical observation data exists; no independent Western RCT, no FDA approval.

Recovery

Suprefort

Suprefort (A-1, Khavinson pancreas cytomax, pancreatic peptide complex)

Khavinson Bioregulators
Evidence: Preclinical

Khavinson cytomax (A-1) pancreas peptide bioregulator. 10 mg natural peptide complex extracted from calf pancreas under 12 months. Russian dietary supplement marketed for pancreatic function, digestion, and glucose metabolism support. No FDA approval.

Recovery

Svetinorm

Svetinorm (A-7, Khavinson liver cytomax, hepatic peptide complex)

Khavinson Bioregulators
Evidence: Preclinical

Khavinson cytomax (A-7) liver peptide bioregulator. Natural peptide complex extracted from calf liver. Russian dietary supplement marketed for liver function support. Synthetic cytogen counterpart is Ovagen. No FDA approval, no Western clinical trials.

Recovery

Testagen

Testagen (Lys-Glu-Asp-Gly, KEDG, Khavinson testicular bioregulator)

Khavinson Bioregulators
Evidence: Preclinical

Khavinson tetrapeptide bioregulator (Lys-Glu-Asp-Gly) targeting testicular tissue. Proposed to support Leydig cell function and endogenous testosterone biosynthesis. Sold in Russia as dietary supplement. No FDA approval, no Western clinical trials.

Recovery

Testoluten

Testoluten A-7 — Khavinson Testicular Cytomax

Khavinson Bioregulators
Evidence: Preclinical

Khavinson testicular Cytomax peptide complex extracted from young calf testis. Marketed for testosterone-axis and reproductive support. Russian-network clinical observation data only.

Recovery

Thymalin

Thymalin (Thymic Polypeptide Bioregulator, calf thymus extract)

Khavinson Bioregulators
Evidence: Approved

Polypeptide complex extracted from calf thymus. The foundational Khavinson cytomedin developed at the Military Medical Academy St. Petersburg. Approved in Russia as immunomodulator since 1982. 6-8 year elderly study with Epithalamin showed mortality reduction. No FDA approval.

Recovery

Thymogen

Thymogen (Glu-Trp, EW dipeptide, L-glutamyl-L-tryptophan)

Khavinson Bioregulators
Evidence: Approved

Synthetic dipeptide (L-Glu-L-Trp) isolated from Thymalin as its principal active component. Russian-approved pharmaceutical since 1990 in three formulations (IM injection, nasal spray, topical cream). Used clinically for immunomodulation. No FDA approval.

Recovery

Ventfort

Ventfort A-3 — Khavinson Vascular Wall Cytomax

Khavinson Bioregulators
Evidence: Preclinical

Khavinson vascular Cytomax extracted from young calf aortic tissue. Contains a complex of peptides up to ~10 kDa. Marketed for vessel function. No Western RCT, no FDA approval, evidence base is Russian-institution dominated.

Recovery

Vesilute

Glutamyl-Aspartate (Glu-Asp / ED) — Khavinson Bladder Cytogen

Khavinson Bioregulators
Evidence: Preclinical

Synthetic Glu-Asp dipeptide developed by the Khavinson group as a bladder cytogen. Evidence is dominated by Russian-institution publications. No FDA approval, no Western RCT, no peer-reviewed pharmacokinetic data.

Recovery

Vesugen

Vesugen (Lys-Glu-Asp, KED tripeptide, Khavinson vascular bioregulator)

Khavinson Bioregulators
Evidence: Preclinical

Khavinson tripeptide bioregulator (Lys-Glu-Asp) targeting vascular endothelium. Developed at the St. Petersburg Institute of Bioregulation and Gerontology. Russian preclinical research only. No Western clinical trials. Available as supplement in Russia.

Tissue Healing

Vilon

Vilon (Lys-Glu, KE dipeptide, Khavinson thymus bioregulator)

Khavinson Bioregulators
Evidence: Preclinical

Khavinson dipeptide bioregulator (Lys-Glu) targeting thymus and immune system. Developed at the St. Petersburg Institute of Bioregulation and Gerontology. Animal studies report immune restoration in aged animals and lifespan extension. No Western clinical trials.

Recovery

Zhenoluten

Zhenoluten — Khavinson Female Reproductive Cytomax

Khavinson Bioregulators
Evidence: Preclinical

Khavinson female reproductive Cytomax peptide complex extracted from young calf ovarian tissue. Marketed for female reproductive support and menopausal symptoms.

Recovery

Khavinson Bioregulators

Khavinson bioregulators are short peptides (mostly 2 to 4 amino acids) developed at the Saint Petersburg Institute of Bioregulation and Gerontology under Vladimir Khavinson from the 1970s onward. The peptides are sold under the Cytomax and Cytogen brand names in Russia and are marketed as tissue-specific signaling molecules that interact with DNA to regulate gene expression in their target organ.

The category is large. Each peptide is named for the tissue it claims to target. Epitalon (Glu-Asp-Glu-Gly) is the pineal-derived peptide and the most discussed bioregulator outside Russia. It has the largest body of preclinical literature, including rodent studies reporting increased telomerase activity and modest lifespan extension in CBA mice. Other named bioregulators include Bronchogen (lung), Thymogen (thymus), Pinealon (pineal), Vesugen (vascular), and many more.

The evidence base is almost entirely preclinical and concentrated in a single research group. Human studies, where they exist, are typically open-label, small, observational, and published in Russian-language journals without independent replication or placebo control. No Western randomized controlled trial has been published for any Khavinson bioregulator.

No Khavinson bioregulator is approved by the FDA, EMA, or any other major Western regulator. They are sold in Russia and online as supplements, not as pharmaceuticals. Research Use Only labels apply in most other jurisdictions.

The mechanism story is plausible at a high level and not directly verified at the molecular detail Khavinson claims. Independent replication of the lifespan and telomerase findings remains the open question for this category.